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Coffee inhibits the reactivation of glucocorticoids by 11β‐hydroxysteroid dehydrogenase type 1: A glucocorticoid connection in the anti‐diabetic action of coffee?
Author(s) -
Atanasov Atanas G.,
Dzyakanchuk Anna A.,
Schweizer Roberto A.S.,
Nashev Lyubomir G.,
Maurer Evelyne M.,
Odermatt Alex
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2006.06.046
Subject(s) - glucocorticoid , 11β hydroxysteroid dehydrogenase type 1 , connection (principal bundle) , dehydrogenase , endocrinology , action (physics) , medicine , chemistry , biology , enzyme , biochemistry , mathematics , physics , geometry , quantum mechanics
Recent epidemiological studies demonstrated a beneficial effect of coffee consumption for the prevention of type 2 diabetes, however, the underlying mechanisms remained unknown. We demonstrate that coffee extract, corresponding to an Italian Espresso, inhibits recombinant and endogenous 11β‐hydroxysteroid dehydrogenase type 1 (11β‐HSD1) activity. The inhibitory component is heat‐stable with considerable polarity. Coffee extract blocked 11β‐HSD1‐dependent cortisol formation, prevented the subsequent nuclear translocation of the glucocorticoid receptor and abolished glucocorticoid‐induced expression of the key gluconeogenic enzyme phosphoenolpyruvate carboxykinase. We suggest that at least part of the anti‐diabetic effects of coffee consumption is due to inhibition of 11β‐HSD1‐dependent glucocorticoid reactivation.