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Tumor necrosis factor‐α and interleukin‐1β increases CTRP1 expression in adipose tissue
Author(s) -
Kim Kun-yong,
Kim Hwa Young,
Kim Jae Hyeong,
Lee Chul-Ho,
Kim Do-Hyung,
Lee Young Ho,
Han Seung Hyun,
Lim Jong-Seok,
Cho Dae Ho,
Lee Myeong-Sok,
Yoon Sukjoon,
Kim Keun Il,
Yoon Do-Young,
Yang Young
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2006.06.034
Subject(s) - adipose tissue , endocrinology , medicine , chemistry , inflammation , tumor necrosis factor alpha , gene expression , gene , biology , biochemistry
CTRP1, a member of the CTRP superfamily, consists of an N‐terminal signal peptide sequence followed by a variable region, a collagen repeat domain, and a C‐terminal globular domain. CTRP1 is expressed at high levels in adipose tissues of LPS‐stimulated Sprague‐Dawley rats. The LPS‐induced increase in CTRP1 gene expression was found to be mediated by TNF‐α and IL‐1β. Also, a high level of expression of CTRP1 mRNA was observed in adipose tissues of Zucker diabetic fatty ( fa/fa ) rats, compared to Sprague‐Dawley rats in the absence of LPS stimulation. These findings indicate that CTRP1 expression may be associated with a low‐grade chronic inflammation status in adipose tissues.