Premium
Acute oxidative stress is associated with cell proliferation in the mouse liver
Author(s) -
Dragin Nadine,
Smani Moneïm,
Arnaud-Dabernat Sandrine,
Dubost Clément,
Moranvillier Isabelle,
Costet Pierre,
Daniel Jean-Yves,
Peuchant Evelyne
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2006.06.006
Subject(s) - oxidative stress , paraquat , cell growth , liver regeneration , microbiology and biotechnology , apoptosis , oxidative phosphorylation , signal transduction , regeneration (biology) , cell , necrosis , biology , programmed cell death , chemistry , biochemistry , genetics
Oxidative stress is known to produce tissue injury and to activate various signaling pathways. To investigate the molecular events linked to acute oxidative stress in mouse liver, we injected a toxic dose of paraquat. Liver necrosis was first observed, followed by histological marks of cell proliferation. Concomitantly, activation of the MAP kinase pathway and increased levels of the anti‐apoptotic protein Bcl‐X L were observed. Gene expression profiles revealed that the differentially expressed genes were potentially involved in cell proliferation. These data suggest that paraquat‐induced acute oxidative stress triggers the activation of regeneration‐related events in the liver.