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Goat SRY induces testis development in XX transgenic mice
Author(s) -
Pannetier Maëlle,
Tilly Gaëlle,
Kocer Ayhan,
Hudrisier Marthe,
Renault Lauriane,
Chesnais Nathalie,
Costa José,
Le Provost Fabienne,
Vaiman Daniel,
Vilotte Jean-Luc,
Pailhoux Eric
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2006.05.060
Subject(s) - testis determining factor , biology , transgene , gene , genetically modified mouse , sex reversal , disorders of sex development , genetics , function (biology) , conserved sequence , microbiology and biotechnology , y chromosome , base sequence
The testis‐determining gene SRY is not well‐conserved among mammals, particularly between mouse and other mammals, both in terms of protein structure and of expression regulation. To evaluate SRY phylogenic conservation in regards to its function, we expressed the goat gene ( gSRY ) in XX transgenic mouse gonads. Here, we show that gSRY induces testis formation, despite a goat expression profile. Our results demonstrate that sex‐reversal can be induced in XX‐mice by a non‐mouse SRY thus suggesting a conserved molecular mechanism of action of this testis‐determining gene across mammalian species.