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Expression and functional characterization of the putative protein 8b of the severe acute respiratory syndrome‐associated coronavirus
Author(s) -
Law Pui Ying Peggy,
Liu Yuet-Man,
Geng Hua,
Kwan Ka Ho,
Waye Mary Miu-Yee,
Ho Yuan-Yuan
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2006.05.051
Subject(s) - coronavirus , covid-19 , respiratory system , betacoronavirus , severe acute respiratory syndrome , biology , medicine , virology , immunology , pathology , disease , outbreak , infectious disease (medical specialty)
SARS 8b is one of the putative accessory proteins of the severe acute respiratory syndrome‐associated coronavirus (SARS‐CoV) with unknown functions. In this study, the cellular localization and activity of this estimated 9.6 kDa protein were examined. Confocal microscopy results indicated that SARS 8b is localized in both nucleus and cytoplasm of mammalian cells. Functional study revealed that overexpression of SARS 8b induced DNA synthesis. Coexpression of SARS 8b and SARS 6, a previously characterized SARS‐CoV accessory protein, did not elicit synergistic effects on DNA synthesis.