Premium
PolydA and polyrA self‐structured by a europium and amino acid complex
Author(s) -
Zhang Haiyuan,
Yu Haijia,
Ren Jinsong,
Qu Xiaogang
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2006.05.046
Subject(s) - europium , chemistry , valine , dna , amino acid , aspartic acid , rna , duplex (building) , salt (chemistry) , stereochemistry , biochemistry , organic chemistry , gene , ion
Different DNA selectivity was found for the newly synthesized europium– l ‐valine complex. Unexpected DNA and RNA selection results showed that europium– l ‐valine complex can cause single‐stranded polydA and polyrA to self‐structure. The sigmoidal melting curve profiles indicate the transition is cooperative, similar to the cooperative melting of a duplex DNA. This is different from another europium amino acid complex, europium– l ‐aspartic acid complex which can induce B‐Z transition under the low salt condition. To our knowledge, there is no report to show that a metal–amino acid complex can cause the self‐structuring of single‐stranded DNA and RNA.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom