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Oxidative damage of periodontal tissue in the rat periodontitis model: Effects of a high‐cholesterol diet
Author(s) -
Tomofuji Takaaki,
Azuma Tetsuji,
Kusano Hiroki,
Sanbe Toshihiro,
Ekuni Daisuke,
Tamaki Naofumi,
Yamamoto Tatsuo,
Watanabe Tatsuo
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2006.05.041
Subject(s) - cholesterol , periodontitis , lipopolysaccharide , high cholesterol , oxidative phosphorylation , cytokine , proteases , oxidative stress , chemistry , inflammation , medicine , endocrinology , biology , biochemistry , enzyme
Studies suggest an association between consumption of a high‐cholesterol diet and periodontitis. We addressed the mechanism by which high dietary cholesterol could be detrimental to periodontal health in a rat model. Feeding a high‐cholesterol diet augmented the effects of bacterial pathogens and their products (e.g., lipopolysaccharide and proteases) on production of pro‐inflammatory cytokines in fibroblasts. High dietary cholesterol also increased mitochondrial 8‐hydroxydeoxyguanosine in the periodontal tissues. These results suggest that excessive tissue oxidative damage induced by high dietary cholesterol could potentiate pro‐inflammatory cytokine production by fibroblasts stimulated with bacterial pathogens.