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CLIP‐region mediated interaction of Invariant chain with MHC class I molecules
Author(s) -
Powis Simon J.
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2006.04.060
Subject(s) - cd74 , mhc class ii , major histocompatibility complex , mhc class i , peptide , residue (chemistry) , chemistry , mhc restriction , molecule , stereochemistry , biology , biochemistry , gene , organic chemistry
An association between the MHC class II chaperone molecule Invariant chain (Ii) and MHC class I molecules is known to occur, but the basis of the interaction is undetermined. Evidence is presented here that the CLIP region of Ii is involved in this interaction. A peptide encoding residues 91–99 of CLIP (MRMATPLLM) stabilised multiple MHC class I alleles, with the methionine residue at position 99 having a crucial role in binding to H2‐K b , whereas methionine at position 91 also appeared important in binding to RT1‐A a . Ii can also be detected in the class I MHC peptide loading complex. These data provide an explanation for the association of Ii and MHC class I molecules.