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Integrated genome‐wide gene expression map and high‐resolution analysis of aberrant chromosomal regions in squamous cell lung cancer
Author(s) -
Zhang Xin-Yu,
Hu Ying,
Cui Yong-Ping,
Miao Xiao-Ping,
Tian Feng,
Xia Yong-Jing,
Wu Yi-Qing,
Liu Xiangjun
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2006.04.043
Subject(s) - loss of heterozygosity , biology , comparative genomic hybridization , xq28 , genome , lung cancer , gene , cancer , microarray , genetics , cancer research , computational biology , gene expression , phenotype , pathology , medicine , allele
The recognition of recurrent aberrant regions in cancer is important to the discovery of candidate cancer related genes. Here we first constructed a genome‐wide gene expression map of squamous lung carcinoma from the Stanford Microarray Database. High‐resolution detection of aberrant chromosomal regions was performed by using moving‐median method. 84% (27 of 32) of our results were consistent with the previous studies of comparative genomic hybridization or loss of heterozygosity. One overrepresented region in Xq28 was newly discovered to be related to squamous cell lung carcinoma. These observations could be of great interest for further studies.