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Mouse model of human infertility: Transient and local inhibition of endometrial STAT‐3 activation results in implantation failure
Author(s) -
Nakamura Hitomi,
Kimura Tadashi,
Koyama Shinsuke,
Ogita Kazuhide,
Tsutsui Tateki,
Shimoya Koichiro,
Taniguchi Takeshi,
Koyama Masayasu,
Kaneda Yasufumi,
Murata Yuji
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2006.04.029
Subject(s) - decidualization , infertility , stat protein , implantation failure , stat , medicine , andrology , cancer research , endometrium , biology , microbiology and biotechnology , signal transduction , stat3 , pregnancy , genetics
Embryo implantation involves a series of biochemical reactions and its failure is an important therapeutic target of infertility treatment. We established an infertile mouse model using transient and local suppression of signal transducer and activator of transcription‐3 (STAT‐3) activity by STAT‐3 decoy transfer into the uterine cavity during implantation, resulting in <30% implantation. This infertility is caused by suppression of decidualization, which is indispensable for implantation, and independent of progesterone. These conditions may mimic clinically unexplained infertility. Our results suggest that STAT‐3 could be a useful target for diagnosis and therapy of human implantation failure.