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Comparative analysis of iron regulated genes in mycobacteria
Author(s) -
Yellaboina Sailu,
Ranjan Sarita,
Vindal Vaibhav,
Ranjan Akash
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2006.03.090
Subject(s) - gene , operon , biology , mycobacterium smegmatis , mycobacterium , microbiology and biotechnology , genome , mycobacterium tuberculosis , gene cluster , bacteria , genetics , tuberculosis , escherichia coli , medicine , pathology
Iron dependent regulator, IdeR, regulates the expression of genes in response to intracellular iron levels in M. tuberculosis . Orthologs of IdeR are present in all the sequenced genomes of mycobacteria. We have used a computational approach to identify conserved IdeR regulated genes across the mycobacteria and the genes that are specific to each of the mycobacteria. Novel iron regulated genes that code for a predicted 4‐hydroxy benzoyl coA hydrolase (Rv1847) and a protease dependent antibiotic regulatory system (Rv1846c, Rv0185c) are conserved across the mycobacteria. Although Mycobacterium natural‐resistance‐associated macrophage protein (Mramp) is present in all mycobacteria, it is, as predicted, an iron‐regulated gene in only one species, M. avium subsp. paratuberculosis . We also observed an additional iron‐regulated exochelin biosynthetic operon, which is present only in non‐pathogenic Mycobacterium , M. smegmatis .