Premium
Biology of vascular endothelial growth factors
Author(s) -
Roy Himadri,
Bhardwaj Shalini,
Ylä-Herttuala Seppo
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2006.03.087
Subject(s) - lymphangiogenesis , angiogenesis , vascular endothelial growth factor c , receptor tyrosine kinase , vascular endothelial growth factor , biology , microbiology and biotechnology , placental growth factor , vascular endothelial growth factor a , vegf receptors , cancer research , kinase , genetics , metastasis , cancer
Angiogenesis is the process by which new blood vessels are formed from existing vessels. The vascular endothelial growth factors (VEGFs) are considered as key molecules in the process of angiogenesis. The VEGF family currently includes VEGF‐A, ‐B, ‐C, ‐D, ‐E, ‐F and placenta growth factor (PlGF), that bind in a distinct pattern to three structurally related receptor tyrosine kinases, denoted VEGF receptor‐1, ‐2, and ‐3. VEGF‐C and VEGF‐D also play a crucial role in the process of lymphangiogenesis. Here, we review the biology of VEGFs and evaluate their role in pathological angiogenesis and lymphangiogenesis.