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Cyclic nucleotide‐gated ion channels in sensory transduction
Author(s) -
Pifferi Simone,
Boccaccio Anna,
Menini Anna
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2006.03.086
Subject(s) - cyclic nucleotide gated ion channel , transduction (biophysics) , visual phototransduction , ion channel , sensory system , cyclic nucleotide , neuroscience , calmodulin , olfactory system , signal transduction , olfaction , chemistry , microbiology and biotechnology , biology , biophysics , nucleotide , biochemistry , gene , retina , receptor , enzyme
Cyclic nucleotide‐gated (CNG) channels, directly activated by the binding of cyclic nucleotides, were first discovered in retinal rods, cones and olfactory sensory neurons. In the visual and olfactory systems, CNG channels mediate sensory transduction by conducting cationic currents carried primarily by sodium and calcium ions. In olfactory transduction, calcium in combination with calmodulin exerts a negative feedback on CNG channels that is the main molecular mechanism responsible for fast adaptation in olfactory sensory neurons. Six mammalian CNG channel genes are known and some human visual disorders are caused by mutations in retinal rod or cone CNG genes.