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The spindle assembly checkpoint: Preventing chromosome mis‐segregation during mitosis and meiosis
Author(s) -
Malmanche Nicolas,
Maia André,
Sunkel Claudio E.
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2006.03.081
Subject(s) - chromosome segregation , spindle checkpoint , meiosis , aneuploidy , biology , mitosis , kinetochore , meiosis ii , g2 m dna damage checkpoint , microbiology and biotechnology , cell cycle checkpoint , spindle apparatus , genetics , chromosome , cell cycle , cancer , cell division , gene , cell
Aneuploidy is a common feature of many cancers, suggesting that genomic stability is essential to prevent tumorigenesis. Also, during meiosis, chromosome non‐disjunction produces gamete imbalance and when fertilized result in developmental arrest or severe birth defects. The spindle assembly checkpoint prevents chromosome mis‐segregation during both mitosis and meiosis. In mitosis, this control system monitors kinetochore‐microtubule attachment while in meiosis its role is still unclear. Interestingly, recent data suggest that defects in the spindle assembly checkpoint are unlikely to cause cancer development but might facilitate tumour progression. However, in meiosis a weakened checkpoint could contribute to age‐related aneuploidy found in humans.