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Suppression of Mycobacterium tuberculosis induced reactive oxygen species (ROS) and TNF‐α mRNA expression in human monocytes by allicin
Author(s) -
Hasan Nazarul,
Yusuf Nabiha,
Toossi Zahra,
Islam Najmul
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2006.03.071
Subject(s) - allicin , reactive oxygen species , tumor necrosis factor alpha , mycobacterium tuberculosis , inflammation , monocyte , downregulation and upregulation , chemistry , tuberculosis , macrophage , immunology , microbiology and biotechnology , biology , medicine , biochemistry , in vitro , gene , pathology
Chronic inflammation associated with tumor necrosis factor (TNF)‐α and reactive oxygen species (ROS) is the hallmark of tuberculosis. Mycobacterium tuberculosis (MTB) directly stimulates human monocytes to secrete TNF‐α. We show the augmented expression of TNF‐α mRNA in MTB‐infected monocytes by cellular activation and ROS was suppressed by allicin in a dose‐dependent manner. Also, allicin enhanced the glutathione peroxidase activity, which correlated inversely with the downregulation of ROS and TNF‐α in MTB‐infected monocytes. Hence, allicin may prove to be a valuable natural antioxidant in combating tuberculosis.