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Expression of human PQBP‐1 in Drosophila impairs long‐term memory and induces abnormal courtship
Author(s) -
Yoshimura Natsue,
Horiuchi Daisuke,
Shibata Masao,
Saitoe Minoru,
Qi Mei-ling,
Okazawa Hitoshi
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2006.03.056
Subject(s) - biology , courtship , ctd , transgene , drosophila (subgenus) , microbiology and biotechnology , gene , neuroscience , genetics , zoology , geology , oceanography
Frame shift mutations of the polyglutamine binding protein‐1 ( PQBP1 ) gene lead to total or partial truncation of the C‐terminal domain (CTD) and cause mental retardation in human patients. Interestingly, normal Drosophila homologue of PQBP‐1 lacks CTD. As a model to analyze the molecular network of PQBP‐1 affecting intelligence, we generated transgenic flies expressing human PQBP‐1 with CTD. Pavlovian olfactory conditioning revealed that the transgenic flies showed disturbance of long‐term memory. In addition, they showed abnormal courtship that male flies follow male flies. Abnormal functions of PQBP‐1 or its binding partner might be linked to these symptoms.