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Growth factor receptors in helminth parasites: Signalling and host–parasite relationships
Author(s) -
Dissous Colette,
Khayath Naji,
Vicogne Jérôme,
Capron Monique
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2006.03.046
Subject(s) - parasite hosting , helminths , receptor , biology , host (biology) , zoology , ecology , genetics , world wide web , computer science
Parasitic helminths remain major pathogens of both humans and animals throughout the world. The success of helminth infections depends on the capacity of the parasite to counteract host immune responses but also to exploit host‐derived signal molecules for its development. Recent progress has been made in the characterization of growth factor receptors of various nematode and flatworm parasites with the demonstration that transforming growth factor beta (TGF‐β), epidermal growth factor (EGF) and insulin receptor signalling pathways are conserved in helminth parasites and potentially implicated in the host–parasite molecular dialogue and parasite development.