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Reversible inhibition of caspase‐3 activity by iron(III)
Author(s) -
Sliskovic Inga,
Mutus Bulent
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2006.03.031
Subject(s) - chemistry , apoptosis , caspase , in vivo , caspase 3 , biochemistry , poly adp ribose polymerase , chelation , protein disulfide isomerase , caspase 9 , microbiology and biotechnology , enzyme , programmed cell death , biology , polymerase , organic chemistry
Desferoxamine is known to induce apoptosis in cancer cells, but the mechanisms are still not fully understood. We have shown that iron(III) is a potent caspase‐3 inhibitor, and the inhibition is reversible by the iron chelating agent desferoxamine. Also, protein disulfide isomerase (PDI) is capable of activating caspase‐3 inhibited by iron(III), likely by formation of iron–sulfur complex through its active site thiols. Data presented here suggests that iron(III) could be a potential inhibitor of apoptosis in vivo, by caspase‐3‐dependent inhibition with a possibility of recovery through PDI overexpression.