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Epigallocatechin‐3‐gallate protects toluene diisocyanate‐induced airway inflammation in a murine model of asthma
Author(s) -
Kim Seung-Hun,
Park Hee-Ju,
Lee Chang-Min,
Choi Il-Whan,
Moon Dong-Oh,
Roh Hwan-Jung,
Lee Hern-Ku,
Park Yeong-Min
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2006.02.052
Subject(s) - toluene diisocyanate , inhalation , chemistry , inflammation , reactive oxygen species , matrix metalloproteinase , cytokine , catechin , immunology , copd , pharmacology , medicine , biochemistry , antioxidant , polyphenol , anesthesia , organic chemistry , polyurethane
Epigallocatechin‐3‐gallate (EGCG), a major form of tea catechin, has anti‐allergic properties. To elucidate the anti‐allergic mechanisms of EGCG, we investigated its regulation of matrix metalloproteinase (MMP‐9) expression in toluene diisocyanate (TDI)‐inhalation lung tissues as well as TNF‐α and Th2 cytokine (IL‐5) production in BAL fluid. Compared with untreated asthmatic mice those administrated with EGCG had significantly reduced asthmatic reaction. Also, increased reactive oxygen species (ROS) generation by TDI inhalation was diminished by administration of EGCG in BAL fluid. These results suggest that EGCG regulates inflammatory cell migration possibly by suppressing MMP‐9 production and ROS generation, and indicate that EGCG may be useful as an adjuvant therapy for bronchial asthma.