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The diverse involvement of heterogeneous nuclear ribonucleoprotein K in mitochondrial response to insulin
Author(s) -
Dzwonek Artur,
Mikula Michał,
Ostrowski Jerzy
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2006.02.043
Subject(s) - heterogeneous nuclear ribonucleoprotein , ribonucleoprotein , heterogeneous ribonucleoprotein particle , hspa9 , microbiology and biotechnology , atp–adp translocase , mitochondrion , rna binding protein , biology , mitochondrial dna , rna , gene , biochemistry , inner mitochondrial membrane , peptide sequence
Heterogeneous nuclear ribonucleoprotein K (hnRNP K protein) is an RNA/DNA‐binding protein that acts in several compartments, including mitochondria. It integrates cellular signaling cascades with multiple processes of gene expression mechanisms. Our studies demonstrate that: (1) insulin activates the import of hnRNP K protein into mitochondria in vitro and in vivo; (2) overexpression of hnRNP K protein modulates insulin‐activated mitochondrial gene expression; and (3) insulin treatment stimulates binding of hnRNP K protein to mitochondrial DNA. Based on these and our previously reported results we conclude that hnRNP K protein may be a mediator of mitochondrial response to insulin.