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Expression of mouse liver receptor homologue 1 in embryonic stem cells is directed by a novel promoter
Author(s) -
Gao Da-ming,
Wang Lin-fang,
Liu Jing,
Kong Yu-ying,
Wang Yuan,
Xie You-hua
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2006.02.017
Subject(s) - biology , embryonic stem cell , embryogenesis , microbiology and biotechnology , embryo , stem cell , gene , genetics
Liver receptor homologue 1 (LRH‐1) plays important roles in many physiological processes and embryogenesis. However, little is known about the developmental regulation of lrh‐1 expression. We identified a novel transcript of mouse lrh‐1 ( mlrh‐1v2 ) from embryonic stem (ES) cells. mlrh‐1v2 is expressed throughout embryogenesis and in several adult tissues, while the known transcript ( mlrh‐1v1 ) appears later during embryogenesis. mlrh‐1v2 expression is directed by a new promoter which displays a strong activity in ES cells. The generation of the new transcript is conserved in rats. The identification of novel mlrh‐1 variant and promoter is critical for elucidating LRH‐1 functions in development and adult tissues.