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Fibroblast growth factor signaling in embryonic and cancer stem cells
Author(s) -
Dvorak Petr,
Dvorakova Dana,
Hampl Ales
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2006.01.095
Subject(s) - embryonic stem cell , fibroblast growth factor , microbiology and biotechnology , biology , stem cell , progenitor cell , carcinogenesis , cancer stem cell , fibroblast growth factor receptor , cancer research , stem cell factor , fibroblast growth factor receptor 2 , fibroblast growth factor receptor 3 , cancer , receptor , genetics , gene
The fibroblast growth factor 2 (FGF‐2) pathway is one of the most significant regulators of human embryonic stem cell (hESC) self‐renewal and cancer cell tumorigenesis. Here we summarize recent data on the effects of FGF‐2 and its receptors on hESCs and leukemic stem/progenitor cells. Also, we discuss the similarities of these findings with stem cell renewal and differentiation phenotypes.