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A possible role of exon‐shuffling in the evolution of signal peptides of human proteins
Author(s) -
Vibranovski Maria Dulcetti,
Sakabe Noboru Jo,
de Souza Sandro José
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2006.01.094
Subject(s) - intron , exon , splice , rna splicing , shuffling , cleavage (geology) , splice site mutation , exon shuffling , gene , genetics , signal peptide , biology , alternative splicing , chemistry , peptide sequence , rna , paleontology , fracture (geology) , computer science , programming language
It was recently shown that there is a predominance of phase 1 introns near the cleavage site of signal peptides encoded by human genes [Tordai, H. and Patthy, L. (2004) Insertion of spliceosomal introns in proto‐splice sites: the case of secretory signal peptides. FEBS Lett. 575, 109–111]. It was suggested that this biased distribution was due to intron insertion at AG∣G proto‐splice sites. However, we found that there is no disproportional excess of AG∣G that would support insertion at proto‐splice sites. In fact, all nG∣G sites are enriched in the vicinity of the cleavage site. Additional analyses support an alternative scenario in which exon‐shuffling is largely responsible for such excess of phase 1 introns.