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p8 Upregulation sensitizes astrocytes to oxidative stress
Author(s) -
Carracedo Arkaitz,
Egia Ainara,
Guzmán Manuel,
Velasco Guillermo
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2006.01.084
Subject(s) - oxidative stress , downregulation and upregulation , heme oxygenase , p38 mitogen activated protein kinases , microbiology and biotechnology , oxidative phosphorylation , heme , chemistry , protein kinase a , sensitization , kinase , biology , biochemistry , gene , immunology , enzyme
Here we studied the mechanism of cell sensitization to oxidative stress by analyzing the gene expression profile of serum‐deprived astrocytes. Exposure to serum‐free medium (i) sensitized astrocytes to oxidative stress, (ii) reduced the expression of several genes involved in protection against oxidative stress, including heme oxygenase 1, and (iii) changed the expression of several genes involved in the control of cell survival, including the stress‐regulated protein p8. Our results support that serum deprivation sensitizes astrocytes to oxidative stress via a p38 mitogen‐activated protein kinase‐dependent p8 upregulation that leads in turn to decreased heme oxygenase 1 expression.