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Functional and evolutionary analyses on expressed intronless genes in the mouse genome
Author(s) -
Sakharkar Kishore Ramaji,
Sakharkar Meena Kishore,
Culiat Cymbeline T.,
Chow Vincent T.K.,
Pervaiz Shazib
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2006.01.070
Subject(s) - gene , genome , biology , housekeeping gene , genetics , human genome , computational biology , conserved sequence , gene expression , base sequence
Using computational approaches we have identified 2017 expressed intronless genes in the mouse genome. Evolutionary analysis reveals that 56 intronless genes are conserved among the three domains of life – bacteria, archea and eukaryotes. These highly conserved intronless genes were found to be involved in essential housekeeping functions. About 80% of expressed mouse intronless genes have orthologs in eukaryotic genomes only, and thus are specific to eukaryotic organisms. 608 of these genes have intronless human orthologs and 302 of these orthologs have a match in OMIM database. Investigation into these mouse genes will be important in generating mouse models for understanding human diseases.