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Does the proteome encode organellar pH?
Author(s) -
Brett Christopher L.,
Donowitz Mark,
Rao Rajini
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.12.103
Subject(s) - encode , proteome , chemistry , computational biology , biology , biochemistry , gene
Inherent to the proteome itself, may be information that enables proteins to buffer pH at a level that promotes their own function within a specialized compartment. We observe that the distribution of computed isoelectric points in the yeast proteome matches experimentally derived organellar pH estimates across distinct subcellular compartments. This raises an interesting evolutionary question: did the p I of proteins and the pH of organelles co‐evolve to optimize function?