Premium
Expression of APOBEC2 is transcriptionally regulated by NF‐κB in human hepatocytes
Author(s) -
Matsumoto Tomonori,
Marusawa Hiroyuki,
Endo Yoko,
Ueda Yoshihide,
Matsumoto Yuko,
Chiba Tsutomu
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.12.081
Subject(s) - tumor necrosis factor alpha , protein subunit , gene expression , nf κb , biology , microbiology and biotechnology , untranslated region , enzyme , nfkb1 , inflammation , messenger rna , microrna , gene , function (biology) , regulation of gene expression , chemistry , biochemistry , signal transduction , transcription factor , immunology
Apolipoprotein B mRNA‐editing enzyme catalytic subunit 2 (APOBEC2) is a member of the nucleic‐acid‐editing enzymes. However, the physiological function of APOBEC2 remains unclear. We demonstrate that APOBEC2 expression is strongly enhanced in response to both tumour necrosis factor‐α (TNF‐α) and interleukin‐1β. Inhibition of NF‐κB activation invariably blocks TNF‐α‐induced APOBEC2 expression. The promoter region of APOBEC2 contains functional NF‐κB response elements in the 5′ untranslated region of the gene at −625/−616. These results show that APOBEC2 expression is regulated by pro‐inflammatory cytokines via NF‐κB activation and suggest a possible role of APOBEC2 in the pathophysiology of hepatic inflammation.