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GG: A domain involved in phage LTF apparatus and implicated in human MEB and non‐syndromic hearing loss diseases
Author(s) -
Guo Jinhu,
Cheng Haipeng,
Zhao Shouyuan,
Yu Long
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.12.076
Subject(s) - bacteriophage , biology , gene , protein domain , domain (mathematical analysis) , mannose , genetics , horizontal gene transfer , function (biology) , computational biology , genome , biochemistry , escherichia coli , mathematical analysis , mathematics
Here, we report the identification of a novel domain – GG (domain in KIAA1199, FAM3, POMGnT1 and Tmem2 proteins, with two well‐conserved glycine residues), present in eukaryotic FAM3 superfamily (FAM3A, FAM3B, FAM3C and FAM3D), POMGnT1 (protein O‐linked mannose β‐1,2‐ N ‐acetylglucosaminyltransferase), TEM2 proteins as well as phage gp35 proteins. GG domain has been revealed to be implicated in muscle–eye–brain disease and non‐syndromic hearing loss. The presence of GG domain in Bacteriophage gp35 hinge connector of long tail fiber might reflect the horizontal gene transfer from organisms. And we proposed that GG domain might function as important structural element in phage LTF.