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The molecular basis of multidrug resistance in cancer: The early years of P‐glycoprotein research
Author(s) -
Gottesman Michael M.,
Ling Victor
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.12.060
Subject(s) - multiple drug resistance , p glycoprotein , efflux , disease , cancer , biology , computational biology , drug resistance , medicine , genetics
The discovery and characterization of P‐glycoprotein, an energy‐dependent multidrug efflux pump, as a mechanism of multidrug resistance in cancer is generally accepted as a significant contribution to the ongoing effort to end death and suffering from this disease. The historical reflections of Victor Ling and Michael Gottesman concerning the early years of this research highlight the important contributions of the multidisciplinary teams involved in these studies, and illustrate how technological developments in biochemistry and molecular and cell biology enabled this discovery.