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Adaptive response induced by lipid peroxidation products in cell cultures
Author(s) -
Chen Zhi-Hua,
Yoshida Yasukazu,
Saito Yoshiro,
Noguchi Noriko,
Niki Etsuo
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.12.045
Subject(s) - lysophosphatidylcholine , lipid peroxidation , hormesis , oxidative stress , 4 hydroxynonenal , reactive oxygen species , chemistry , biochemistry , phosphatidylcholine , phospholipid , membrane
The adaptive response induced by the lipid peroxidation products, such as phosphatidylcholine hydroperoxide, lysophosphatidylcholine (LysoPC), 15‐deoxy‐Δ 12,14 ‐prostaglandin J 2 , 4‐hydroxynonenal (4‐HNE), hydroxyoctadecadienoic acid, 7‐hydroxycholesterol, and cholesterol 5β,6β‐epoxide, was investigated in this study. Although these products have been implicated in oxidative stress‐related diseases, pretreatment with such compounds at sublethal concentrations significantly protected PC12 cells against subsequent oxidative stress induced by 6‐hydroxydopamine. Moreover, 4‐HNE and LysoPC also exhibited adaptive protection in human arterial endothelial cells. These findings suggest a general hormetic effect of such compounds in cell cultures and may lead to a reappraisal of the eventual role of reactive oxygen species and lipid peroxidation in organisms.