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Mammalian mitochondrial nitric oxide synthase: Characterization of a novel candidate
Author(s) -
Zemojtel Tomasz,
Kolanczyk Mateusz,
Kossler Nadine,
Stricker Sigmar,
Lurz Rudi,
Mikula Ivan,
Duchniewicz Marlena,
Schuelke Markus,
Ghafourifar Pedram,
Martasek Pavel,
Vingron Martin,
Mundlos Stefan
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.12.038
Subject(s) - nitric oxide synthase , nitric oxide , microbiology and biotechnology , mitochondrion , context (archaeology) , atp synthase , biology , biochemistry , chemistry , enzyme , paleontology , endocrinology
Recently a novel family of putative nitric oxide synthases, with AtNOS1, the plant member implicated in NO production, has been described. Here we present experimental evidence that a mammalian ortholog of AtNOS1 protein functions in the cellular context of mitochondria. The expression data suggest that a candidate for mammalian mitochondrial nitric oxide synthase contributes to multiple physiological processes during embryogenesis, which may include roles in liver haematopoesis and bone development.