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Novel bioactive parathyroid hormone and related peptides in teleost fish
Author(s) -
Canario Adelino V.M.,
Rotllant Josep,
Fuentes Juan,
Guerreiro Pedro M.,
Rita Teodósio H.,
Power Deborah M.,
Clark Melody S.
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.12.023
Subject(s) - parathyroid hormone , takifugu rubripes , medicine , endocrinology , parathyroid hormone receptor , hormone , fish <actinopterygii> , biology , gene , phylogenetic tree , chemistry , calcium , biochemistry , hormone receptor , fishery , cancer , breast cancer
We report the identification, gene expression and biological activity of two parathyroid hormones (PTH; PTHA and PTHB), two PTH‐related peptides (PTHrP; PTHrPA and PTHrPB) and a PTH‐like ligand (PTH‐L) with hybrid characteristics in puffer fishes ( Takifugu rubripes and Tetraodon fluviatilis ). Experimental data are consistent with PTH‐L and PTHrPA having calciotropic activities equivalent, respectively, to tetrapod PTH and PTHrP. We hypothesise on the basis of phylogenetic and functional analysis that PTH‐L could be a fish relic of an ancestral PTH/PTHrP gene.