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Arabidopsis KRPs have distinct inhibitory activity toward cyclin D2‐associated kinases, including plant‐specific B‐type cyclin‐dependent kinase
Author(s) -
Nakai Tomohiro,
Kato Ko,
Shinmyo Atsuhiko,
Sekine Masami
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.12.018
Subject(s) - cyclin dependent kinase , cyclin dependent kinase complex , cyclin , microbiology and biotechnology , kinase , cyclin dependent kinase 2 , biology , cyclin dependent kinase 4 , arabidopsis , chemistry , biochemistry , protein kinase a , cell cycle , gene , mutant
Arabidopsis contains seven Kip‐related protein (KRP) genes encoding CDK (cyclin‐dependent kinase) inhibitors (CKIs), which shares a restricted similarity with mammalian p27 Kip1 . Here, we analyze the characteristics of the KRPs. Although KRP1–KRP7 interact with active cyclin D2 (CYCD2)/CDKA and CYCD2/CDKB complexes to a similar extent, they inhibit kinase activity to a different extent. Our results suggest that inhibitory activity is related to the binding ability between KRP proteins and cyclin/CDK complexes, but secondary and tertiary structure may be also involved. These data provide the first evidence that KRPs inhibit kinase activity associated with plant‐specific CDKB.