Premium
Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium
Author(s) -
Locovei Silviu,
Wang Junjie,
Dahl Gerhard
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.12.004
Subject(s) - pannexin , calcium , receptor , chemistry , microbiology and biotechnology , cytoplasm , p2y receptor , biophysics , biochemistry , biology , purinergic receptor , gap junction , intracellular , connexin , organic chemistry
The ability for long‐range communication through intercellular calcium waves is inherent to cells of many tissues. A dual propagation mode for these waves includes passage of IP3 through gap junctions as well as an extracellular pathway involving ATP. The wave can be regenerative and include ATP‐induced ATP release via an unknown mechanism. Here, we show that pannexin 1 channels can be activated by extracellular ATP acting through purinergic receptors of the P2Y group as well as by cytoplasmic calcium. Based on its properties, including ATP permeability, pannexin 1 may be involved in both initiation and propagation of calcium waves.