Premium
The ABC of auxin transport: The role of p‐glycoproteins in plant development
Author(s) -
Geisler Markus,
Murphy Angus S.
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.11.054
Subject(s) - auxin , subfamily , arabidopsis , biology , function (biology) , atp binding cassette transporter , gene , plant hormone , genetics , transporter , genome , computational biology , microbiology and biotechnology , mutant
A surprising outcome of the Arabidopsis genome project was the annotation of a large number of sequences encoding members of the ABC transporter superfamily, including 22 genes encoding the p‐glycoprotein (PGP) subfamily. As mammalian PGP orthologs are associated with multiple drug resistance, plant PGPs were initially presumed to function in detoxification, but were soon seen to have a developmental role. Here, we summarise recent studies of plant PGPs indicating that PGPs mediate the cellular and long‐distance transport of the plant hormone auxin. One class of PGPs, represented by AtPGP1, catalyze auxin export, while another class with at least one member, AtPGP4, appears to function in auxin import. Current models on the physiological role of PGPs, their functional interaction and their involvement in cell‐to cell (polar) auxin transport are discussed.