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9α,11β‐PGF 2 and its stereoisomer PGF 2α are novel agonists of the chemoattractant receptor, CRTH2
Author(s) -
Sandig Hilary,
Andrew David,
Barnes Ashley A.,
Sabroe Ian,
Pease James
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.11.052
Subject(s) - metabolite , chemotaxis , receptor , agonist , chemistry , prostaglandin , prostaglandin d2 , in vivo , allergic inflammation , pharmacology , inflammation , biochemistry , microbiology and biotechnology , biology , immunology , genetics
CRTH2 is a recently described chemoattractant receptor for the prostaglandin, PGD 2 , expressed by Th2 cells, eosinophils and basophils, and believed to play a role in allergic inflammation. Here we describe the potency of several PGD 2 metabolites at the receptor to induce cell migration and activation. We report for the first time that the PGD 2 metabolite, 9α,11β‐PGF 2 , and its stereoisomer, PGF 2α , are CRTH2 agonists. 9α,11β‐PGF 2 is a major metabolite produced in vivo following allergen challenge, whilst PGF 2α is generated independently of PGD synthetase, with implications for CRTH2 signalling in the presence or absence of PGD 2 production.