9α,11β‐PGF 2  and its stereoisomer PGF 2α  are novel agonists of the chemoattractant receptor, CRTH2 | Zendy

Sandig Hilary | Zendy; Andrew David | Zendy; Barnes Ashley A. | Zendy; Sabroe Ian | Zendy; Pease James | Zendy

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9α,11β‐PGF 2 and its stereoisomer PGF 2α are novel agonists of the chemoattractant receptor, CRTH2

Author(s) -

Sandig Hilary,

Andrew David,

Barnes Ashley A.,

Sabroe Ian,

Pease James

Publication year - 2006

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2005.11.052

Subject(s) - metabolite , chemotaxis , receptor , agonist , chemistry , prostaglandin , prostaglandin d2 , in vivo , allergic inflammation , pharmacology , inflammation , biochemistry , microbiology and biotechnology , biology , immunology , genetics

CRTH2 is a recently described chemoattractant receptor for the prostaglandin, PGD 2 , expressed by Th2 cells, eosinophils and basophils, and believed to play a role in allergic inflammation. Here we describe the potency of several PGD 2 metabolites at the receptor to induce cell migration and activation. We report for the first time that the PGD 2 metabolite, 9α,11β‐PGF 2 , and its stereoisomer, PGF 2α , are CRTH2 agonists. 9α,11β‐PGF 2 is a major metabolite produced in vivo following allergen challenge, whilst PGF 2α is generated independently of PGD synthetase, with implications for CRTH2 signalling in the presence or absence of PGD 2 production.

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