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Expression of Musashi‐1 in the rat stomach and changes during mucosal injury and restitution
Author(s) -
Nagata Hiroshi,
Akiba Yasutada,
Suzuki Hidekazu,
Okano Hideyuki,
Hibi Toshifumi
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.11.041
Subject(s) - stem cell , microbiology and biotechnology , pathology , biology , stomach , downregulation and upregulation , cellular differentiation , stem cell marker , medicine , biochemistry , gene
Musashi‐1 is involved in maintenance of neural stem cells. In the rat stomach, we found some cells in the luminal compartment of the mucosa that stained positively for Musashi‐1. These cells were distinct from other cells of epithelial lineage, except for parietal cells, and coexpressed HES5. The Musashi‐1‐positive cells exfoliated after damage, while Musashi‐1 expression in neck cells were upregulated, and proliferating cells diminished before reappearing and increasing in number thereafter. We conclude that a subpopulation of parietal cells acts as a source of Musashi‐1, which contributes to rapid re‐epithelization by restoration of stem cells and regulation of cell differentiation.