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Membrane topology of human ABC proteins
Author(s) -
Tusnády Gábor E.,
Sarkadi Balázs,
Simon István,
Váradi András
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.11.040
Subject(s) - topology (electrical circuits) , membrane topology , membrane protein , computational biology , domain (mathematical analysis) , membrane , computer science , biology , biochemistry , mathematics , combinatorics , mathematical analysis
In this review, we summarize the currently available information on the membrane topology of some key members of the human ABC protein subfamilies, and present the predicted domain arrangements. In the lack of high‐resolution structures for eukaryotic ABC transporters this topology is based only on prediction algorithms and biochemical data for the location of various segments of the polypeptide chain, relative to the membrane. We suggest that topology models generated by the available prediction methods should only be used as guidelines to provide a basis of experimental strategies for the elucidation of the membrane topology.