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The structures of MsbA: Insight into ABC transporter‐mediated multidrug efflux
Author(s) -
Reyes Christopher L.,
Ward Andrew,
Yu Jodie,
Chang Geoffrey
Publication year - 2006
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.11.033
Subject(s) - efflux , atp binding cassette transporter , transporter , multiple drug resistance , atp hydrolysis , membrane transport protein , biochemistry , chemistry , biology , multidrug resistance associated proteins , multidrug resistance associated protein 2 , enzyme , atpase , gene , antibiotics
ATP‐binding cassette (ABC) transporters are integral membrane proteins that couple ATP hydrolysis to the transport of various molecules across cellular membranes. Found in both prokaryotes and eukaryotes, a sub‐group of these transporters are involved in the efflux of hydrophobic drugs and lipids, causing anti‐microbial and chemotherapeutic multidrug resistance. In this review, we examine recent structural and functional analysis of the ABC transporter MsbA and implications on the mechanism of multidrug efflux.