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Nitric oxide mediates anti‐inflammatory action of extracorporeal shock waves
Author(s) -
Ciampa Anna R.,
de Prati Alessandra Carcereri,
Amelio Ernesto,
Cavalieri Elisabetta,
Persichini Tiziana,
Colasanti Marco,
Musci Giovanni,
Marlinghaus Ernst,
Suzuki Hisanori,
Mariotto Sofia
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.11.023
Subject(s) - nitric oxide , nitric oxide synthase , tumor necrosis factor alpha , chemistry , nf κb , interferon gamma , mechanism of action , pharmacology , microbiology and biotechnology , medicine , immunology , biochemistry , biology , signal transduction , in vitro , organic chemistry
Here, we show that extracorporeal shock waves (ESW), at a low energy density value, quickly increase neuronal nitric oxide synthase (nNOS) activity and basal nitric oxide (NO) production in the rat glioma cell line C6. In addition, the treatment of C6 cells with ESW reverts the decrease of nNOS activity and NO production induced by a mixture of lipopolysaccharides (LPS), interferon‐γ (IFN‐γ) plus tumour necrosis factor‐α (TNF‐α). Finally, ESW treatment efficiently downregulates NF‐κB activation and NF‐κB‐dependent gene expression, including inducible NOS and TNF‐α. The present report suggests a possible molecular mechanism of the anti‐inflammatory action of ESW treatment.