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Transgenic potato expressing Aβ reduce Aβ burden in Alzheimer's disease mouse model
Author(s) -
Youm Jung Won,
Kim Hee,
Han Jee Hye Lo,
Jang Chang Hwan,
Ha Hee Jin,
Mook-Jung Inhee,
Jeon Jae Heung,
Choi Cheol Yong,
Kim Young Ho,
Kim Hyun Soon,
Joung Hyouk
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.11.003
Subject(s) - transgene , genetically modified mouse , amyloid precursor protein , amyloid (mycology) , alzheimer's disease , biology , genetically modified crops , immune system , disease , bace1 as , tandem repeat , gene , immunology , medicine , genome , biochemistry , pathology , botany
Beta amyloid (Aβ) is believed one of the major pathogens of Alzheimer's disease (AD), and the reduction of Aβ is considered a primary therapeutic target. Immunization with Aβ can reduce Aβ burden and pathological features in transgenic AD model mice. Transgenic potato plants were made using genes encoding 5 tandem repeats of Aβ1–42 peptides with an ER retention signal. Amyloid precursor protein transgenic mice (Tg2576) fed with transgenic potato tubers with adjuvant showed a primary immune response and a partial reduction of Aβ burden in the brain. Thus, Aβ tandem repeats can be expressed in transgenic potato plants to form immunologically functional Aβ, and these potatoes has a potential to be used for the prevention and treatment of AD.