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Sulfite facilitates LDL lipid oxidation by transition metal ions: A pro‐oxidant in wine?
Author(s) -
Laggner Hildegard,
Hermann Marcela,
Sturm Brigitte,
Gmeiner Bernhard M.K.,
Kapiotis Stylianos
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.10.045
Subject(s) - sulfite , chemistry , sulfite oxidase , radical , wine , pro oxidant , lipid oxidation , transition metal , metal ions in aqueous solution , aqueous solution , antioxidant , inorganic chemistry , metal , organic chemistry , catalysis , food science
Lipid oxidation in LDL may play a role in atherogenesis. It has been shown that sulfite – a compound in the aqueous fraction of wine – could inhibit free radical (AAPH) mediated oxidation of plasma. Thus, sulfite has been proposed as an antioxidant. In contrast, the aqueous phase of wine has recently been shown to contain not fully identified compounds promoting transition metal ion (Cu 2+ ) initiated LDL oxidation. As transition metal ions can catalyse the auto‐oxidation of sulfite, we studied the influence of sulfite on Cu 2+ initiated LDL oxidation. The results show that sulfite at concentrations found in vivo strongly facilitated LDL oxidation by Cu 2+ . The LDL‐oxidase activity of ceruloplasmin was also stimulated by sulfite. ROS formation byCu 2 + / SO 3 2 ‐was not inhibited by SOD but by catalase. We propose that formation of Cu + , sulfite radicals ( SO 3 − )and hydroxyl radicals (OH) is a mechanism by which sulfite could act as a pro‐atherogenic agent in presence of transition metal ions.