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2‐Arachidonoylglycerol, an endogenous cannabinoid receptor ligand, enhances the adhesion of HL‐60 cells differentiated into macrophage‐like cells and human peripheral blood monocytes
Author(s) -
Gokoh Maiko,
Kishimoto Seishi,
Oka Saori,
Metani Yasuchika,
Sugiura Takayuki
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.10.030
Subject(s) - microbiology and biotechnology , cell adhesion , chemistry , cell adhesion molecule , u937 cell , fibronectin , neural cell adhesion molecule , immune system , extracellular matrix , biology , cell , biochemistry , immunology , apoptosis
2‐Arachidonoylglycerol (2‐AG), an endogenous cannabionoid receptor (CB1 and CB2) ligand, enhanced the adhesion of HL‐60 cells differentiated into macrophage‐like cells to fibronectin and the vascular cell adhesion molecule‐1. The CB2 receptor, Gi/Go, intracellular free Ca 2+ and phosphatidylinositol 3‐kinase were shown to be involved in 2‐AG‐induced augmented cell adhesion. 2‐AG also enhanced the adhesion of human monocytic leukemia U937 cells and peripheral blood monocytes. These results strongly suggest that 2‐AG plays some essential role in inflammatory reactions and immune responses by inducing robust adhesion to extracellular matrix proteins and adhesion molecules in several types of inflammatory cells and immune‐competent cells.