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Stg1 is a novel SM22/transgelin‐like actin‐modulating protein in fission yeast
Author(s) -
Nakano Kentaro,
Bunai Fumihide,
Numata Osamu
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.10.011
Subject(s) - cytokinesis , schizosaccharomyces pombe , microbiology and biotechnology , actin , actin cytoskeleton , yeast , cytoskeleton , fission , actin remodeling of neurons , biology , schizosaccharomyces , mdia1 , actin remodeling , formins , actin binding protein , chemistry , saccharomyces cerevisiae , cell , biochemistry , cell division , neutron , physics , quantum mechanics
We identified a novel actin‐modulating protein Stg1 in the fission yeast Schizosaccharomyces pombe . Stg1 is similar to mammalian SM22/transgelin, and biochemical experiments showed that Stg1 crosslinked F‐actin. Microscopic observation suggested that Stg1 was a component of actin patch. Overexpression of Stg1 caused a defect in cytokinesis by suppressing the formation of a contractile ring and formation of abnormal aggregates of F‐actin in the ends and mid‐region of cells. Although distribution of the actin cytoskeleton was not affected by disrupting stg1 + , genetic interaction suggested that Stg1 was likely involved in controlling the organization of the actin cytoskeleton in cell morphogenesis and cytokinesis in fission yeast.