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Differentiation of circulating endothelial progenitor cells to a cardiomyogenic phenotype depends on E‐cadherin
Author(s) -
Koyanagi Masamichi,
Urbich Carmen,
Chavakis Emmanouil,
Hoffmann Jörg,
Rupp Stefan,
Badorff Cornel,
Zeiher Andreas M.,
Starzinski-Powitz Anna,
Haendeler Judith,
Dimmeler Stefanie
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.09.071
Subject(s) - progenitor cell , cadherin , microbiology and biotechnology , progenitor , ve cadherin , regeneration (biology) , phenotype , endothelial stem cell , endothelial progenitor cell , integrin , biology , stem cell , cell , chemistry , immunology , in vitro , genetics , gene
Progenitor cells may contribute to cardiac regeneration. Here, we investigated the role of cadherins and integrins for differentiation of human adult circulating endothelial progenitor cells (EPCs) into cardiomyocytes (CM) in a co‐culture system. N‐ and E‐cadherin were expressed in EPCs and were localized at the interface between EPCs and CM. Incubation of a blocking antibody against E‐cadherin reduced the expression of CM marker protein in EPCs. Blocking antibodies against N‐ or P‐cadherin or the β1‐ and β2‐integrins were not effective. These data suggested that cell‐to‐cell communication mediated by E‐cadherin contributes to the acquirement of a cardiomyogenic phenotype of human endothelial progenitor cells.