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The adiponectin paralog CORS‐26 has anti‐inflammatory properties and is produced by human monocytic cells
Author(s) -
Weigert Johanna,
Neumeier Markus,
Schäffler Andreas,
Fleck Martin,
Schölmerich Jürgen,
Schütz Christian,
Buechler Christa
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.09.022
Subject(s) - secretion , adiponectin , microbiology and biotechnology , biology , tumor necrosis factor alpha , biochemistry , immunology , endocrinology , insulin resistance , insulin
The adiponectin paralog CORS‐26 (collagenous repeat‐containing sequence of 26 kDa protein) is a member of the C1q/TNF‐α molecular superfamily. CORS‐26 is a secreted protein and baculovirus‐produced CORS‐26 released in the supernatant of insect cells forms stable trimers. Adiponectin exerts anti‐inflammatory effects in LPS‐treated monocytic cells and CORS‐26 also reduces IL‐6 and TNF‐α secretion but does not increase IL‐10. Suppression of NFκB signalling may explain the anti‐inflammatory actions of CORS‐26. Furthermore CORS‐26 protein was detected in human monocytic and dendritic cells. The present data demonstrate for the first time that CORS‐26 forms trimers, exerts anti‐inflammatory properties and that it is expressed in monocytic cells. Therefore CORS‐26 may provide a new target for pharmacological drugs in inflammatory diseases like the metabolic syndrome.