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Seasonal environmental changes regulate the expression of the histone variant macroH2A in an eurythermal fish
Author(s) -
Pinto Rodrigo,
Ivaldi Corinne,
Reyes Mauricio,
Doyen Cécile,
Mietton Flore,
Mongelard Fabien,
Alvarez Marco,
Molina Alfredo,
Dimitrov Stefan,
Krauskopf Manuel,
Vera Maria Ines,
Bouvet Philippe
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.09.019
Subject(s) - fish <actinopterygii> , histone , microbiology and biotechnology , biology , gene expression , genetics , fishery , gene
Adaptation to cold and warm conditions requires dramatic change in gene expression. The acclimatization process of the common carp Cyprinus carpio L. in its natural habitat has been used to study how organisms respond to natural environmental changes. At the cellular level, adaptation to cold condition is accompanied by a dramatic alteration in nucleolar structure and a down regulation of the expression of ribosomal genes. We show that the enrichment of condensed chromatin in winter adapted cells is not correlated with an increase of the heterochromatin marker trimethyl and monomethyl K20H4. However, the expression of the tri methyl K4 H3 and of the variant histone macroH2A is significantly increased during the winter season together with a hypermethylation of CpG residues. Taking into account the properties of macroH2A toward chromatin structure and dynamics and its role in gene repression our data suggest that the increased expression of macroH2A and the hypermethylation of DNA which occurs upon winter‐acclimatization plays a major role for the reorganization of chromatin structure and the regulation of gene expression during the physiological adaptation to a colder environment.