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Comparative simulations of aquaporin family: AQP1, AQPZ, AQP0 and GlpF
Author(s) -
Hashido Masanori,
Ikeguchi Mitsunori,
Kidera Akinori
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.09.018
Subject(s) - aquaporin , water transport , water channel , chemistry , aquaporin 1 , permeability (electromagnetism) , environmental chemistry , biology , membrane , environmental science , biochemistry , water flow , environmental engineering , mechanical engineering , engineering , inlet
Molecular dynamics simulations were performed for four members of the aquaporin family (AQP1, AQPZ, AQP0, and GlpF) in the explicit membrane environment. The single‐channel water permeability, p f , was evaluated to be GlpF ∼ AQPZ >AQP1 ≫ AQP0, while their relative pore sizes were GlpF ≫ AQP1 >AQPZ ≫ AQP0. This relation between p f and pore size indicates that water permeability was determined not only by the channel radius, but also another competing factor. Analysis of water dynamics revealed that this factor was the single‐file nature of water transport.