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Selective regulation of cellular processes via protein cascades acting as band‐pass filters for time‐limited oscillations
Author(s) -
Marhl Marko,
Perc Matjaž,
Schuster Stefan
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.09.007
Subject(s) - biophysics , chemistry , biological system , physics , microbiology and biotechnology , biology
We show by mathematical modelling that a two‐level protein cascade can act as a band‐pass filter for time‐limited oscillations. The band‐pass filters are then combined into a network of three‐level signalling cascades that by filtering the frequency of time‐limited oscillations selectively switches cellular processes on and off. The physiological relevance for the selective regulation of cellular processes is demonstrated for the case of regulation by time‐limited calcium oscillations.