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One‐compound‐multiple‐targets strategy to combat Alzheimer's disease
Author(s) -
Zhang Hong-Yu
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.09.006
Subject(s) - drug discovery , monoamine oxidase , drug , disease , neuroscience , amyloid precursor protein , alzheimer's disease , drug development , pharmacology , chemistry , medicine , biology , bioinformatics , biochemistry , enzyme
The present one‐drug‐one‐target paradigm in drug discovery has been considered partially responsible for the more‐funding‐less‐drug predicament in modern pharmaceutical industry. To hit the multiple targets implicated in complex diseases, two strategies, based on multicomponent or single‐ingredient, are conceivable. Although the latter is more difficult to be fulfilled than the former, the recent progress made in the fight against Alzheimer's disease (AD) has brought us the first light of success of the latter strategy. In this review, both synthetic and natural multipotent agents are described, which hit two or more targets implicated in AD, e.g., acetylcholinesterase, monoamine oxidase, amyloid‐β, τ protein, metal ions and reactive oxygen species. Nevertheless, due to the potential risks in safety, absorbability and pharmacokinetics of synthetic multipotent agents, natural counterparts seem more promising in the future development.